揭校园贷巨额诈骗:涉案大学生出手阔绰有专职司机
百度 “复制‘雄县模式’的关键在于，政府理念的推广应优先于经济理念的推广。
Pharmacology is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function.
426 questions
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Are there any drugs that are "repulsive" (the opposite of addictive)?
I’m not talking about drugs that treat addiction.
I’m asking if there are drugs that, when taken, cause you to develop a negative association with it and want to stop taking it.
I thought ...
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0
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49
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Therapeutic index of the cancer drug Tafinlar (dabrafenib)
I am struggling to find the therapeutic index of the cancer drug Tafinlar (dabrafenib), which is used to treat melanoma. I have reviewed the prescribing information and searched for the drug name with ...
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1
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0
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93
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Lipid solubility of drugs and their absorption
As part of my research in the field of AI, I am supposed to understand some basics of pharmacology and I have some doubts with regards to the following statement I read in the textbook - Stahl's ...
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3
votes
1
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Test Strains Permit Question
I am in the works of setting up a brand new micro lab for a small company, and I am trying to figure out the microbe test strains I'd need. My company is creating ivermectin injection products and ...
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0
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Modified G protein for GPCR-ligand interactions
Would a G protein that does not break down prolong the G-protein coupled receptor (GPCR)'s attachment to its ligand?
For example, if the G protein in T1R3-T1R2 did not break, will the "sweet"...
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3
votes
0
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33
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Statistics for ratios to wildtype growth
I have a large dataset that represents a library of yeast deletion mutants and their growth under treatment from a compound. In the library alongside the mutants is a wild-type strain and I want to ...
0
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1
answer
228
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What would happen if somebody was administered caffeine while sleeping?
I know that drinking caffeine before sleep can disrupt your sleep and REM cycle, but I was wondering what would happen if hypothetically someone slept for 8 or so hours before being administered a ...
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2
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1
answer
328
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Cell viability assay: Problems with MTT assay in the solubilization step
I am testing two compounds against 3 cell lines to determine cell viability. Two lines grow in Eagle media, one in DMEM (+10 Percent bovine serum) which contain phenyl red indicator.
I prepared 3 ...
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For Cytotox studies of anticancer compounds: What cell line can I use to check if my compounds will also damage healthy cells?
I am about to perform cytotox studies on cells with my synthesized compounds.
I want to test my structures against MCF7 cells (breast cancer) as well as a melanoma cell line. MCF7 should be vunerable ...
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1
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1
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How much effort is it to establish a cytotox assay for cancer cell lines against a small number of possible compounds?
I am currently testing a series (5-10) of small molecule compounds against an enzyme that are intended as inhibitors. This enzyme is meaningful for cell proliferation.
Until now, nothing was active ...
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19
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3
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Are stable isotopes ever used in pharmaceuticals?
Carbon has two stable isotopes, C-12 and C-13. Since they both have the same electronic structure they can both make up the same molecules, but presumably they may perform different functions in ...
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How does the area under the curve mean the total exposure to the drug?
I was wondering how the area under the curve in the case of a conc against time plot would be equal to the total exposure in the body? I know that this area is integrated using
AUC = ∫C dt
However ...
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5
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2
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833
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Why do we not develop tolerance to endogenous factors?
In pharmacology, we studied the development of tolerance to the therapeutic effects of drugs. It is defined as the diminished response of the body to a drug as an adaptation to its continued presence.
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Can drugs be administered through penis?
I was reading this paper on routes of drug administration and noticed that it mentioned intravaginal drug administration. It looks like this is a good way to take drugs because there are a lot of ...
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5
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1
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Are psilocybin/psilocyn the only psychoactive compounds in psychoactive mushrooms?
Psilocybe cubensis is the most common psychedelic mushroom, and its active ingredients are psilocin and psilocybin (which is converted to psilocin in the body).
There are other psychedelic mushrooms, ...
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